Małgorzata Alicja Śliwińska

Translational Fidelity Maintained by ZNF598-Dependent Ribosome Resolution Enables Cellular Adaptation to High Energy Demand

This study identifies ZNF598 as a factor resolving translation stress during metabolic adaptation, showing its role in mitochondrial biogenesis and metabolic flexibility.

Phagocytes as Plaque Catalysts: Human Macrophages Actively Generate Pathogenic Aβ42 Fibrils with Seeding and Cross-Seeding Potency

This study shows human macrophages and microglia actively produce Aβ42 fibrils, which seed amyloid plaques and tau aggregation, and this process is influenced by genetic factors like TREM2.

Projections from thalamic nucleus reuniens to hippocampal CA1 area participate in context fear extinction by affecting extinction-induced molecular remodeling of excitatory synapses

This study shows that thalamic nucleus reuniens projections to hippocampal CA1 regulate context fear extinction by modulating synaptic molecular remodeling in specific strata.

Phosphorylation of PSD-95 at Serine 73 in dCA1 is required for extinction of contextual fear

This study identifies phosphorylation of PSD-95 at Serine 73 in dCA1 as necessary for extinction of contextual fear memory.

Synaptic plasticity regulated by phosphorylation of PSD-95 Serine 73 in dorsal CA1 is required for contextual fear extinction

This study shows that phosphorylation of PSD-95 at serine 73 is required for contextual fear extinction but not for fear memory formation or recall.

Ultrastructural Visualization of 3D Chromatin Folding Using Serial Block-Face Scanning Electron Microscopy and In Situ Hybridization (3D-EMISH)

This paper develops a new electron microscopy method to visualize 3D chromatin folding at ultra-resolution in human cells and finds high heterogeneity in chromatin structures.

Contribution of PSD-95 protein to reward location memory

This study shows that PSD-95 downregulation and its phosphorylation by CaMKII are critical for reward location memory in young mice, but alternative mechanisms support memory in aged mice.