Simon Bekker‐Jensen

RNF25 restrains GCN2 hyperactivation to sustain protein synthesis and cell proliferation in response to RNA damage

This study identifies RNF25 as a regulator of GCN2 activity during RNA damage, showing that RNF25 prevents excessive GCN2 activation to maintain protein synthesis and cell proliferation.

Translational Fidelity Maintained by ZNF598-Dependent Ribosome Resolution Enables Cellular Adaptation to High Energy Demand

This study identifies ZNF598 as a factor resolving translation stress during metabolic adaptation, showing its role in mitochondrial biogenesis and metabolic flexibility.

ZAKα is a sensor of mRNA stasis at the ribosomal exit channel

The paper identifies ZAKα as a sensor that detects mRNA stasis at the ribosomal exit channel through interactions with ribosomal proteins and rRNA.

Spatial-proteomics reveal in-vivo phospho-signaling dynamics at subcellular resolution

The paper develops a high-throughput workflow for subcellular proteome and phospho-proteome profiling and applies it to study EGFR signaling and stress responses in cells.

Alternative translation initiation generates a functionally distinct isoform of the stress-activated kinase MK2

The paper identifies an alternative translation initiation site in MK2 mRNA that generates a long isoform with distinct functional properties compared to the short isoform.