The coronavirus nsp14 exoribonuclease interface with the cofactor nsp10 is essential for efficient virus replication and enzymatic activity.
Samantha L. Grimes, Brook E. Heaton, Mackenzie L. Anderson, Katie Burke, Laura J. Stevens, Xiaotao Lu, Nicholas S. Heaton, Mark R. Denison, Jordan Anderson-Daniels
This study shows that the nsp14-nsp10 interaction is essential for coronavirus replication and enzymatic activity, with specific interface residues critical for function.
Journal of Virology · Jan 10, 2025Peer-reviewedMicrobiology