Author

Samantha L. Grimes

Vanderbilt University Medical CenterORCID 0000-0003-1124-2956Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Brook E. HeatoniD· 1 shared Jordan Anderson-DanielsiD· 1 shared Katie Burke· 1 shared Laura J. StevensiD· 1 shared Mackenzie L. Anderson· 1 shared Mark R. DenisoniD· 1 shared Nicholas S. HeatoniD· 1 shared Xiaotao LuiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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8 top collaborators · 28 mutual co-author links

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1 shared paperMicrobiology

Brook E. HeatonORCID

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1 paper

Recent·Most cited

MicrobiologyJournal of VirologyPeer-reviewedJan 10, 2025

The coronavirus nsp14 exoribonuclease interface with the cofactor nsp10 is essential for efficient virus replication and enzymatic activity.

Samantha L. Grimes, Brook E. Heaton, Mackenzie L. Anderson…·Jordan Anderson-Daniels

This study shows that the nsp14-nsp10 interaction is essential for coronavirus replication and enzymatic activity, with specific interface residues critical for function.

9 citationstop 3%

mouseexperimental assay

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