Nicholas S. Heaton

Pan-Coronavirus Protease Engagement and Differentiated Pharmacology of Antiviral Candidate CMX990

This study evaluates CMX990, a coronavirus Mpro inhibitor, showing broad antiviral activity against multiple coronaviruses and superior pharmacologic properties compared to existing inhibitors.

Elicitation of stem-directed antibodies in rhesus macaques by a conventional hemagglutinin immunogen

This study shows that a conventional H1 HA trimer vaccine elicits stem-directed antibodies in rhesus macaques that provide broad protection against H1N1 and H5N1 influenza.

CGRP reception potentiates anxiety in an influenza A derived immune engram

The paper investigates how an influenza A-derived immune engram influences anxiety and cytokine expression through CGRP signaling in the posterior insula.

Loss of nsp14-exonuclease activity impairs the replication, proofreading, fitness and pathogenesis of SARS-CoV-2

This study shows that SARS-CoV-2 with impaired nsp14-exonuclease activity has reduced replication, fitness, and pathogenesis, but remains viable in some conditions.

Constitutive Interferon Epsilon Expression Shapes Antiviral Epithelial States in the Female Reproductive Tract and Intestine

This study identifies IFN{varepsilon} as a constitutively expressed IFN that maintains antiviral defenses in the female reproductive tract and intestine by sustaining specific epithelial states and type III IFN expression.

Species-specific chromatin architecture and neurogenesis mediated by a human enhancer

The paper shows human-specific enhancer HAR1984 promotes neurogenesis by altering chromatin interactions and gene regulation in cortical organoids and mice.

An integrated workflow for structural virology with a 100 keV electron microscope

This paper describes a user-managed 100 keV electron microscope setup for structural virology, enabling high-quality cryo-EM data collection and analysis within a laboratory setting.

The coronavirus nsp14 exoribonuclease interface with the cofactor nsp10 is essential for efficient virus replication and enzymatic activity.

This study shows that the nsp14-nsp10 interaction is essential for coronavirus replication and enzymatic activity, with specific interface residues critical for function.

The Shigella flexneri effector IpaH1.4 facilitates RNF213 degradation and protects cytosolic bacteria against interferon-induced ubiquitylation

This study identifies IpaH1.4 as a Shigella effector that degrades RNF213, preventing ubiquitylation of intracellular bacteria and evading host immunity.

Single-cell genome-wide association reveals a nonsynonymous variant in ERAP1 confers increased susceptibility to influenza virus

The paper identifies a nonsynonymous ERAP1 variant associated with increased susceptibility to influenza virus using scHi-HOST, a single-cell method for genetic susceptibility testing.