Brain capillary obstruction as a novel mechanism of anti-CD19 CAR T cell neurotoxicity
Lila D. Faulhaber, Kendra Jae Hartsuyker, Anthea Q. Phuong, Yeheun Cho, Katie K. Mand, Stuart D Harper, Aaron K Olson, Gwenn A. Garden, Andy Y. Shih, Juliane Gust
This study identifies brain capillary obstruction and hypoxia as mechanisms of neurotoxicity in CD19-CAR T cell therapy using a mouse model.
bioRxiv · May 25, 2021 · PreprintNeuroscience