This study detects changes in cardiac O-GlcNAcylation during pressure overload hypertrophy using subcellular fractionation and dual antibody analysis, revealing sex-specific and temporal patterns.

Glycobiology · Dec 10, 2025Peer-reviewedMicrobiology

Determining preclinical safety of Aclarubicin in pediatric malignancies

Darleen S. Tu, Aaron K Olson, Kimberly S. Waggie, Nicolas M. Garcia, Virginia J. Hoglund, Stephanie I. Walter, Jenna R. Rosinski, Harini Sadeeshkumar, Radhika A. Patel, Erolcan Sayar, Michael C. Haffner, Lisa Maves, Jacques Neefjes, Jay F. Sarthy, Elizabeth R. Lawlor, Shireen S. Ganapathi

This study evaluates Aclarubicin's safety and efficacy in pediatric cancer models, finding it effective with reduced genotoxicity and cardiotoxicity compared to doxorubicin.

Pediatric Blood & Cancer · Nov 26, 2025Peer-reviewedCancer Biology

A systems genetics approach identifies roles for proteasome factors in heart development and congenital heart defects

Gist H. Farr, Whitaker Reid, Eva H. Hasegawa, Azzam Azzam, Isabelle Young, M. Li, Aaron K Olson, David R. Beier, Lisa Maves

This study identifies proteasome factors as contributors to heart development and congenital heart defects using a systems genetics approach combining transcriptomics, PPI networks, and CRISPR screening in zebrafish.

PLoS Genetics · Aug 26, 2025Peer-reviewedGenetics

Brain capillary obstruction as a novel mechanism of anti-CD19 CAR T cell neurotoxicity

Lila D. Faulhaber, Kendra Jae Hartsuyker, Anthea Q. Phuong, Yeheun Cho, Katie K. Mand, Stuart D Harper, Aaron K Olson, Gwenn A. Garden, Andy Y. Shih, Juliane Gust

This study identifies brain capillary obstruction and hypoxia as mechanisms of neurotoxicity in CD19-CAR T cell therapy using a mouse model.

bioRxiv · May 25, 2021 · PreprintNeuroscience