This study shows that genetic risk variants in endolysosomal network genes correlate with endolysosomal dysfunction in neural cells in Alzheimer's disease.

bioRxiv · Mar 16, 2025 · PreprintNeuroscience

Transcriptomically unique endolysosomal and homeostatic microglia populations in Alzheimer's disease and aged human brain

Katherine E. Prater, Kevin J. Green, Sainath Mamde, Wei Sun, Alexandra Cochoit, C S Smith, Kenneth L. Chiou, Laura M. Heath, Shannon E. Rose, Jesse C. Wiley, Christopher Dirk Keene, Ronald Young Kwon, Noah Snyder‐Mackler, Elizabeth Blue, Benjamin A. Logsdon, , Suman Jayadev

The paper identifies transcriptomically distinct microglia populations in Alzheimer's disease and aged human brains using single-nucleus RNA-seq and trajectory inference.

Nature Aging · May 29, 2023Peer-reviewedNeuroscience

The Neuroscience Multi-Omic Archive: A BRAIN Initiative resource for single-cell transcriptomic and epigenomic data from the mammalian brain

Seth A. Ament, Ricky S. Adkins, Robert Carter, Elena Chrysostomou, Carlo Colantuoni, Jonathan Crabtree, Heather H. Creasy, Kylee Degatano, Victor Felix, Peter Gandt, Gwenn A. Garden, Michelle Gwinn Giglio, Brian R. Herb, Farzaneh Khajouei, Elizabeth A. Kiernan, , Owen R. White

The paper describes the Neuroscience Multi-Omic Archive, a repository for single-cell transcriptomic and epigenomic data from mammalian brains, providing tools for data access and analysis.

Nucleic Acids Research · Nov 1, 2022Peer-reviewedGenomics

Brain capillary obstruction as a novel mechanism of anti-CD19 CAR T cell neurotoxicity

Lila D. Faulhaber, Kendra Jae Hartsuyker, Anthea Q. Phuong, Yeheun Cho, Katie K. Mand, Stuart D Harper, Aaron K Olson, Gwenn A. Garden, Andy Y. Shih, Juliane Gust

This study identifies brain capillary obstruction and hypoxia as mechanisms of neurotoxicity in CD19-CAR T cell therapy using a mouse model.

bioRxiv · May 25, 2021 · PreprintNeuroscience

Molecular estimation of neurodegeneration pseudotime in older brains

Sumit Mukherjee, Laura M. Heath, Christoph Preuß, Suman Jayadev, Gwenn A. Garden, Anna K. Greenwood, Solveig K. Sieberts, Philip L. De Jager, Nilüfer Ertekin‐Taner, Gregory W. Carter, Lara M. Mangravite, Benjamin A. Logsdon

The paper estimates molecular pseudotime for Alzheimer's disease progression using RNA-Seq data from human brain samples, showing strong concordance with pathological markers and cognitive diagnosis.

Nature Communications · Nov 13, 2020Peer-reviewedNeuroscience

Chronic Intermittent Ethanol Activates CHOP in Striatal Microglia and Exacerbates Ethanol Withdrawal

Rapheal G. Williams, Brett D. Dufour, Kevin R. Coffey, Atom J. Lesiak, William B. Nickelson, Aliyah J. Dawkins, Gwenn A. Garden, John F. Neumaier

This study investigates how chronic intermittent ethanol affects microglial translatome in striatum, identifying CHOP and UPR as key factors in ethanol withdrawal symptoms.

bioRxiv · Sep 2, 2020 · PreprintNeuroscience

RiboTag-Seq Reveals a Compensatory cAMP Responsive Gene Network in Striatal Microglia induced by Morphine Withdrawal

Kevin R. Coffey, Atom J. Lesiak, Russell G. Marx, Emily K. Vo, Gwenn A. Garden, John F. Neumaier

The paper uses RiboTag-Seq to show that morphine withdrawal induces a cAMP-responsive gene network in striatal microglia, affecting their morphology and interactions with neurons.

bioRxiv · Feb 10, 2020 · PreprintNeuroscience