Quantitative and Kinetic Proteomics Reveal ApoE Isoform-dependent Proteostasis Adaptations in Mouse Brain
Nathan R. Zuniga, Noah E. Earls, Ariel E. A. Denos, Jared M. Elison, Benjamin S. Jones, Ethan G. Smith, Noah G. Moran, Katie L. Broce, Gerome M. Romero, Chad D. Hyer, Kimberly B. Wagstaff, Haifa M. Almughamsi, Mark K. Transtrum, John C. Price
This study uses quantitative and kinetic proteomics to show that ApoE isoforms 2 and 4 alter mitochondrial protein regulation in the mouse brain compared to ApoE3, with distinct impacts on proteostasis.
PLoS Computational Biology · Dec 12, 2024Peer-reviewedBiochemistry