Author

Mark K. Transtrum

Brigham Young UniversityORCID 0000-0001-9529-9399Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Ariel E. A. Denos· 1 shared Benjamin K. Driggs· 1 shared Benjamin S. JonesiD· 1 shared Bradley C. Naylor· 1 shared Chad D. HyeriD· 1 shared Chad R. Quilling· 1 shared Coleman Nielsen· 1 shared Ethan G. Smith· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperBiochemistry

Ariel E. A. Denos

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3 papers

Recent·Most cited

Kinetic Lipidomics: Quantifying in vivo changes in lipid metabolism using metabolic labeling

Coleman Nielsen, Russell L. Denton, Chad R. Quilling, Kenneth L. Virgin, Kyle J. Cutler, Spencer Gates, Martin Sorensen, Mitchell Poulson, Tayler Hilton, Benjamin K. Driggs, Zabdi Hernandez, Parker Snedaker, Bradley C. Naylor, Mark K. Transtrum, John C. Price

This paper develops a method to quantify lipid metabolism kinetics using deuterium labeling and applies it to brain tissue from mice with Alzheimer's risk factors.

bioRxiv · Jul 1, 2026 · PreprintBiochemistry

Extracting Parsimonious Quantitative Predictors of Biological Effectiveness from 'First-Principles' Radiobiology: Application to the Mixed-Quality Problem

Tahir Yusufaly, Mark K. Transtrum, Livia Huang, S. A. Sabok-Sayr, George Sgouros, Robert F. Hobbs, Xun Jia

This paper reduces a complex radiobiological model to a simpler three-parameter model using MBAM, showing it aligns with known theories and predicts new synergistic effects between radiation types.

bioRxiv · May 6, 2026 · PreprintBiophysics

Quantitative and Kinetic Proteomics Reveal ApoE Isoform-dependent Proteostasis Adaptations in Mouse Brain

Nathan R. Zuniga, Noah E. Earls, Ariel E. A. Denos, Jared M. Elison, Benjamin S. Jones, Ethan G. Smith, Noah G. Moran, Katie L. Broce, Gerome M. Romero, Chad D. Hyer, Kimberly B. Wagstaff, Haifa M. Almughamsi, Mark K. Transtrum, John C. Price

This study uses quantitative and kinetic proteomics to show that ApoE isoforms 2 and 4 alter mitochondrial protein regulation in the mouse brain compared to ApoE3, with distinct impacts on proteostasis.

PLoS Computational Biology · Dec 12, 2024Peer-reviewedBiochemistry