Perturbed cyclic strain results in a mechanically-induced, premature senescent phenotype in cardiac fibroblasts
Stephanie Ellyse Schneider, Adrienne K. Scott, Katie M. Gallagher, Emily Y. Miller, Soham Ghosh, Corey P. Neu
This study shows that perturbed mechanical stretch induces a premature senescent phenotype in cardiac fibroblasts through distinct pathways involving p53/p21 and p16.
bioRxiv · Mar 16, 2025 · PreprintBiophysics