Soham Ghosh

This study shows that Trichostatin A, an HDAC inhibitor, reduces muscle atrophy and preserves nuclear organization in mice subjected to mechanical unloading.

This study investigates how Lamin A/C disruption affects nuclear mechanics, chromatin architecture, and transcription in skeletal muscle in vivo, finding that it alters chromatin organization and gene expression in mechanically stiff tissues.

This paper presents an AI-driven method to convert antibody sequences into functional intrabodies, successfully converting 19 out of 26 sequences, including those targeting histone modifications.

This paper identifies a mechano-epigenetic pathway involving EZH2 that drives phenotypic drift in human MSCs during expansion and shows that EZH2 inhibition preserves stemness and therapeutic potency.

This study shows that substrate stiffness affects doxorubicin-induced apoptosis in HeLa cells by altering cell-cycle state, not cytoskeletal mechanics.

This study investigates how hyperoxia alters chromatin structure in mesenchymal stromal cells using imaging techniques and finds spatiotemporal variability in chromatin remodeling and its inhibition by GSK126.

This study shows that perturbed mechanical stretch induces a premature senescent phenotype in cardiac fibroblasts through distinct pathways involving p53/p21 and p16.

The paper trains a model to predict nuclear shape from cell shape and shows that actomyosin contractility influences nuclear morphology.

This work uses dynamic mode decomposition and optimal control theory to model collective cell migration and simulate single and multi-cellular systems, revealing mathematical rules and potential applications in therapeutic robotics.

This paper develops a biophysical model to predict F-actin stress fiber localization and force during cell migration using cell trajectory data from time lapse microscopy.

This study shows that chromatin remodeling and epigenetic modifications influence cell migration speed and wound closure efficiency on planar substrates.