Conditional knockout of Shank3 in the ventral CA1 by quantitative in vivo genome-editing impairs social memory
Myung Chung, Katsutoshi Imanaka, Ziyan Huang, Akiyuki Watarai, Mu‐Yun Wang, Kentaro Tao, Hirotaka Ejima, Tomomi Aida, Guoping Feng, Teruhiro Okuyama
This study shows that specific Shank3 knockout in ventral CA1 neurons impairs social memory in mice, revealing a threshold for neuronal disruption required for this impairment.
bioRxiv · Jan 22, 2024 · PreprintNeuroscience