Guoping Feng

The paper identifies sibling-derived chimerism in microglia and macrophages across marmoset tissues using single-cell RNA-seq, showing hematopoietic origin and regional variation in brain microglia.

This study shows that miR-206 regulates Purkinje neuron firing dynamics and sensorimotor gating in mice, linking it to schizophrenia-related behaviors.

This paper creates a cross-species spatial transcriptomic atlas of the basal ganglia in human, rhesus macaque, and common marmoset, revealing conserved molecular organization and cell type-specific compartments.

The paper presents a spatially resolved transcriptomic and gene regulatory atlas of primate subcortical regions, revealing spatially tuned transcriptional and regulatory programs across cell types.

The paper develops and benchmarks enhancer-AAVs for selective targeting of midbrain dopaminergic neurons across species, identifying a specific enhancer and optimizing AAV backbones to improve specificity and efficiency.

The paper develops biophysically detailed models of thalamic reticular neurons to study their firing properties and impact on network dynamics.

This study examines Gria3 mutant mice to identify transcriptomic and proteomic changes linked to schizophrenia, finding region-specific gene dysregulation and synaptic protein alterations.

The paper investigates how astrocyte regional specialization develops in mouse and marmoset brains using single-nucleus RNA sequencing and expansion microscopy, finding significant regional and developmental changes in gene expression and morphology.

This study quantifies natural marmoset behavior patterns using a multimodal dataset, showing day-to-day variability and social influences on behavior.

This paper introduces a constitutively active microglia-specific Cre line, Fcrls-2A-Cre, with high recombination efficiency and specificity, suitable for studies where tamoxifen is not feasible.

This study profiles marmoset foveal and peripheral retinal cells across development, revealing conserved cell types and distinct molecular maturation paths.

The paper identifies structurally divergent regions in primate genomes and quantifies the impact of structural variants across multiple species.

This study shows that specific Shank3 knockout in ventral CA1 neurons impairs social memory in mice, revealing a threshold for neuronal disruption required for this impairment.

This study identifies the mediodorsal thalamus as critical for belief dynamics in a schizophrenia mouse model and shows that enhancing its activity rescues cognitive deficits.

The paper analyzes single-nucleus RNA sequencing data from marmoset brain cells to show that neuronal identity is more influenced by developmental origin than functional class.

This study uses single nucleus transcriptomics to compare human and non-human primate cortical tissues, identifying human-specific gene expression patterns and their potential functional roles.

The paper analyzes gene regulatory programs in the neocortex of rodents and primates using single-cell multiomics, finding rapid evolution of cell type-specific gene expression and TE-driven cCREs.

This study compares mitogenome and mtDNA control region markers to determine the ancestry and diversity of captive Callithrix jacchus marmosets, finding mitogenomes provide better resolved phylogenies.

This paper introduces third-generation rabies viral vectors with single deletions that enable more efficient, non-toxic retrograde targeting of projection neurons compared to previous generations.

This study investigates how SAPAP3 deletion affects striatal circuit function in a mouse model of compulsive motor behavior, revealing non-synaptic and pathway-specific changes.

This paper introduces a non-toxic rabies virus system for long-term in vivo imaging of neuronal networks, showing minimal toxicity and normal visual response properties over 10 weeks.

The paper generates a multimodal cell census and atlas of the mammalian primary motor cortex, revealing a unified molecular genetic landscape and cross-species taxonomy of cell types.

The paper profiles interneurons in primates and rodents to identify evolutionary innovations in brain cell types and their molecular features.

The paper identifies enhancers for targeting specific neuronal subtypes across species and demonstrates their utility in circuit manipulation.

In mouse zygotes, prime editing installed 10 modifications across 6 genes, but undesired products such as large deletions outnumbered intended edits, traced to PE3 double-nicking.

This paper introduces two transgenic mouse lines for specific labeling and manipulation of microglia, demonstrating high specificity and minimal off-target effects.

This study identifies VTA GABAergic neurons as critical for visually evoked innate defensive behaviors in mice.

This study demonstrates that RAD51 enhances interhomolog repair in zygotes, enabling efficient homozygous knock-in without exogenous templates.

The paper identifies OCD-associated genes by combining evolutionary and functional data with targeted sequencing in humans and animal models.