Tomomi Aida

This study shows that specific Shank3 knockout in ventral CA1 neurons impairs social memory in mice, revealing a threshold for neuronal disruption required for this impairment.

The paper investigates how memory engrams evolve during consolidation, showing they become selective through inhibitory synaptic plasticity and dynamic composition changes.

In mouse zygotes, prime editing installed 10 modifications across 6 genes, but undesired products such as large deletions outnumbered intended edits, traced to PE3 double-nicking.

This study demonstrates that RAD51 enhances interhomolog repair in zygotes, enabling efficient homozygous knock-in without exogenous templates.