Bystander activation across a TAD boundary supports a cohesin-dependent hub-model for enhancer function
Iain Williamson, Katy A Graham, Hannes Becher, Robert E. Hill, Wendy A. Bickmore, Laura A. Lettice
The paper shows that some Shh enhancers can activate transcription of both Shh and Mnx1 genes across a TAD boundary, supporting a cohesin-dependent hub model for enhancer function.
bioRxiv · Nov 1, 2024 · PreprintGenetics