Deborah Marie Kurrasch

SCN1A haploinsufficiency disrupts neural progenitor networks and accelerates neurogenesis in human Dravet syndrome forebrain assembloids

This study shows that SCN1A haploinsufficiency disrupts neural progenitor networks and accelerates neurogenesis in human Dravet syndrome forebrain assembloids, leading to altered corticogenesis and circuit hyperexcitability.

Inhibition of phosphodiesterase 4B as a novel therapeutic strategy for the treatment of refractory epilepsy

SN-2000, a novel PDE4B inhibitor, reduces seizure activity and shows psychiatric-neutral and pro-cognitive properties in preclinical models.

Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling

The paper shows glycolytic flux promotes rod photoreceptor differentiation by regulating Wnt signaling in murine retinal progenitor cells.

Epileptic phenotypes in slc13a5 loss-of-function zebrafish are rescued by blocking NMDA receptor signaling

This study shows that loss-of-function mutations in zebrafish slc13a5 cause epilepsy-like phenotypes, which are rescued by blocking NMDA receptor signaling.

Sudden unexpected death in epilepsy is prevented by blocking postictal hypoxia

This study shows that blocking postictal hypoxia prevents SUDEP in mice by preventing seizure-induced vasoconstriction.

Hypothalamic vasopressin sex differentiation is established during embryonic neurogenesis

The paper shows that hypothalamic vasopressin neurons are sexually dimorphic during embryonic neurogenesis, with exposure to bisphenol A causing masculinization in female brains.

EXPOSURE TO GLYPHOSATE OR ROUNDUP DURING ZEBRAFISH EMBRYOGENESIS DIFFERENTIALLY AFFECTS METABOLISM AND SWIMMING BEHAVIOURS

This study exposes zebrafish embryos to glyphosate or Roundup and finds differential effects on mitochondrial function and swimming behavior in both F1 and F2 generations.

The Ketogenic Diet Metabolite β-Hydroxybutyrate Promotes Mitochondrial Elongation via Deacetylation in HeLa Cells and Improves Autism-like Behavior in Zebrafish

kcna1a mutant zebrafish as a model of episodic ataxia type 1 and epilepsy

This paper uses zebrafish kcna1a-/- mutants to model EA1 and epilepsy, showing ataxia-like behaviors, brain hyperexcitability, and responsiveness to carbamazepine.

Proneural genes define ground state rules to regulate neurogenic patterning and cortical folding

The paper shows Neurog2 and Ascl1 genes regulate cortical progenitor differentiation and folding through Notch signaling in lissencephalic brains.

A Highly Conserved Shh Enhancer Coordinates Hypothalamic and Craniofacial Development

This study shows that the conserved Shh enhancer SBE2 is critical for maintaining sufficient Shh expression in the rostral diencephalon, which is necessary for proper hypothalamic and craniofacial development.