Coordinated stimulation of axon regenerative and neurodegenerative transcriptional programs by ATF4 following optic nerve injury
Preethi Somasundaram, Madeline M. Farley, Melissa A. Rudy, Katya Sigal, Andoni I. Asencor, David G. Stefanoff, Malay Shah, Puneetha Santoshi Goli, Jenny Heo, Shufang Wang, Nicholas M. Tran, Trent A. Watkins
This study shows ATF4, activated by PERK, coordinates both neurodegenerative and regenerative responses after optic nerve injury in mice.
eLife · Feb 26, 2026Peer-reviewedNeuroscience