Nicholas M. Tran

This study shows ATF4, activated by PERK, coordinates both neurodegenerative and regenerative responses after optic nerve injury in mice.

This paper develops an in vitro model to study human retinal ganglion cell (RGC) connectivity with specific brain regions, showing that cultured RGCs form region-specific synapses with mouse brain targets.

This study examines how optic nerve injury affects the electrophysiological properties of a resilient retinal ganglion cell type, finding reduced firing and intrinsic excitability due to voltage-gated channel dysfunction and Ca2+-dependent mechanisms.

The paper introduces a sample multiplexing method for scRNA-seq to improve resolution of sample origin and phenotypic data in mouse retinal ganglion cells.

The paper generates a large-scale single-cell RNA-seq dataset of the mouse retina and integrates it with public data to create a comprehensive cell atlas.

The paper creates a comprehensive human retina cell atlas using single-cell multi-omics data, revealing over 110 cell types and their gene regulatory networks, and enables fine-mapping of GWAS and eQTL variants.

This study describes the ocular phenotype of homozygous CRX-mutant cats, highlighting severe retinal degeneration and unique features compared to heterozygous models.

The paper identifies transcriptional programs that enhance survival and axon regeneration of injured retinal ganglion cells using single-cell transcriptomics and computational analysis.

This paper identifies 63 amacrine cell types in the mouse retina using scRNA-seq and provides molecular markers, neurotransmitter profiles, and transcription factors for each type.

The paper identifies neuroprotective genes in retinal ganglion cells by analyzing their resilience to injury using single-cell RNA-seq and functional assays.