Author

Preethi Somasundaram

Baylor College of MedicineORCID 0000-0002-2212-2071Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:imaging· 1 Approach:statistical model· 1

Frequent Co-Authors

Trent A. WatkinsiD· 2 shared Anastasia L. Slavutsky· 1 shared Andoni I. AsencoriD· 1 shared Claire E. Le PichoniD· 1 shared David G. StefanoffiD· 1 shared Francisco Manuel Nadal-NicolásiD· 1 shared Jenny HeoiD· 1 shared Jorge Gómez-Deza· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersNeuroscience

Trent A. WatkinsORCID

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2 papers

Recent·Most cited

Coordinated stimulation of axon regenerative and neurodegenerative transcriptional programs by ATF4 following optic nerve injury

Preethi Somasundaram, Madeline M. Farley, Melissa A. Rudy, Katya Sigal, Andoni I. Asencor, David G. Stefanoff, Malay Shah, Puneetha Santoshi Goli, Jenny Heo, Shufang Wang, Nicholas M. Tran, Trent A. Watkins

This study shows ATF4, activated by PERK, coordinates both neurodegenerative and regenerative responses after optic nerve injury in mice.

eLife · Feb 26, 2026Peer-reviewedNeuroscience

DLK-dependent axonal mitochondrial fission drives degeneration following axotomy

Jorge Gómez-Deza, Matthew Nebiyou, Mor R. Alkaslasi, Francisco Manuel Nadal-Nicolás, Preethi Somasundaram, Anastasia L. Slavutsky, Wei Li, Michael Emmerson Ward, Trent A. Watkins, Claire E. Le Pichon

This study develops a human iPSC model of axonal degeneration, identifies DLK-dependent mitochondrial fission as a key mechanism, and shows CRISPR-mediated Drp1 depletion protects neurons from degeneration.

Nature Communications · Dec 30, 2024Peer-reviewedNeuroscience