Trent A. Watkins

This study shows ATF4, activated by PERK, coordinates both neurodegenerative and regenerative responses after optic nerve injury in mice.

This study develops a human iPSC model of axonal degeneration, identifies DLK-dependent mitochondrial fission as a key mechanism, and shows CRISPR-mediated Drp1 depletion protects neurons from degeneration.

This study shows that remyelination protects neurons from DLK-mediated neurodegeneration by preventing apoptosis and inflammation in a mouse model of demyelination.

The paper reanalyzes core transcription programs in retinal ganglion cell neurodegeneration, revealing that previous findings were due to methodological limitations.