mTORC1 Regulates the Metabolic Switch of Postnatal Cardiomyocytes During Regeneration
Wyatt G. Paltzer, Timothy J. Aballo, Jiyoung Bae, Corey G. K. Flynn, Kayla N. Wanless, Katharine A. Hubert, Dakota J. Nuttall, Cassidy Perry, Raya Nahlawi, Ying Ge, Ahmed I. Mahmoud
This study shows that mTORC1 inhibition accelerates the metabolic switch from glycolysis to fatty acid oxidation in neonatal heart injury, impairing regeneration.
bioRxiv · Sep 12, 2023Developmental Biology