Timothy J. Aballo

This study uses proteomics to show that aging, sex, and region affect lung ECM remodeling, with age being the main factor and females showing more pronounced changes.

This study uses quantitative proteomics to identify ECM protein alterations in end-stage ICM, revealing key upregulated components and pathways involved in adverse remodeling.

The paper identifies ssTnI overexpression as enhancing cardiomyocyte proliferation and regenerative capacity post-MI through metabolic shifts.

This study shows that mTORC1 inhibition accelerates the metabolic switch from glycolysis to fatty acid oxidation in neonatal heart injury, impairing regeneration.

The paper uses top-down proteomics to analyze MLC-1 and -2 isoform expression in human heart chambers, revealing chamber-specific patterns and a novel PTM.

This study compares the functional and molecular properties of engineered cardiac tissue constructs made from hiPSC-CMs purified by lactate or MACS methods, finding no significant differences.

The paper develops a multi-omics method to analyze metabolome and proteome of hPSC-CMs, identifying overrepresented pathways in protein synthesis and cardiac function.

The paper introduces an ultrafast proteomics method using Azo and timsTOF Pro to enable high-throughput, reproducible protein identification and quantification from small amounts of human heart tissue.