BiochemistrybioRxiv
Structure of the human Bre1 complex bound to the nucleosome
Shuhei Onishi, Kotone Uchiyama, Ko Sato…·Toru Sengoku
The paper determines the cryo-EM structure of the human Bre1 complex bound to the nucleosome, revealing how it catalyzes H2B monoubiquitination and its potential role in cancer.