Author

Keisuke Hamada

Yokohama City UniversityORCID 0000-0002-8181-9266Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Asako Oguni· 1 shared Chikako Okada· 1 shared Hidetoshi KonoiD· 1 shared Hisashi IshidaiD· 1 shared Kaori FukuzawaiD· 1 shared Ko Sato· 1 shared Osamu NurekiiD· 1 shared Shunsuke KobayashiiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Asako Oguni

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1 paper

Recent·Most cited

Structural insights into inhibition mechanism of the helicase-primase complex from human herpesvirus 1

Ko Sato, Hisashi Ishida, Toma Miyagishi, Shunsuke Kobayashi, Yoshiaki Kise, Keisuke Hamada, Chikako Okada, Asako Oguni, Osamu Nureki, Hidetoshi Kono, Kaori Fukuzawa, Toru Sengoku

This paper reports cryo-EM structures of the HHV1 helicase-primase complex bound to DNA and inhibitors, revealing how these drugs block viral DNA replication by locking the helicase in an inactive conformation.

Cell chemical biology · Apr 15, 2026Peer-reviewedBiochemistry