Structural insights into inhibition mechanism of the helicase-primase complex from human herpesvirus 1
Ko Sato, Hisashi Ishida, Toma Miyagishi, Shunsuke Kobayashi, Yoshiaki Kise, Keisuke Hamada, Chikako Okada, Asako Oguni, Osamu Nureki, Hidetoshi Kono, Kaori Fukuzawa, Toru Sengoku
This paper reports cryo-EM structures of the HHV1 helicase-primase complex bound to DNA and inhibitors, revealing how these drugs block viral DNA replication by locking the helicase in an inactive conformation.
Cell chemical biology · Apr 15, 2026Peer-reviewedBiochemistry