BiochemistryCell chemical biologyPeer-reviewed
Structural insights into inhibition mechanism of the helicase-primase complex from human herpesvirus 1
Ko Sato, Hisashi Ishida, Toma Miyagishi…·Toru Sengoku
This paper reports cryo-EM structures of the HHV1 helicase-primase complex bound to DNA and inhibitors, revealing how these drugs block viral DNA replication by locking the helicase in an inactive conformation.