The interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction
Ahmad Luqman-Fatah, Yuzo Watanabe, Kazuko Uno, Fuyuki Ishikawa, John V. Moran, Tomoichiro Miyoshi
The paper identifies HELZ2 as an ISG protein that inhibits LINE-1 retrotransposition and reduces IFN- induction by interacting with L1 RNA and ORF1p.
Nature Communications · Jan 13, 2023Peer-reviewedMolecular Biology