Tomoichiro Miyoshi

The paper develops a fluorescent reporter to monitor Alu retrotransposition in single cells and shows it can also detect L1 retrotransposition and their co-occurrence.

This study identifies EHF as a negative regulator of senescence-associated secretory phenotype (SASP) by linking it to the p38/NF-κB/IκBζ inflammatory pathway.

This study identifies HERC5 as an ISGylation-independent inhibitor of L1 retrotransposition by reducing ORF1p levels and preventing L1 RNP assembly.

The paper identifies HELZ2 as an ISG protein that inhibits LINE-1 retrotransposition and reduces IFN- induction by interacting with L1 RNA and ORF1p.