The interferon-stimulated gene product HERC5 inhibits human LINE-1 retrotransposition with an ISGylation-independent mechanism
Kei Nishimori, Ahmad Luqman-Fatah, Yuzo Watanabe, Mari Takahashi, Takuhiro Ito, Fuyuki Ishikawa, Tomoichiro Miyoshi
This study identifies HERC5 as an ISGylation-independent inhibitor of L1 retrotransposition by reducing ORF1p levels and preventing L1 RNP assembly.
Nucleic Acids Research · Apr 8, 2026Peer-reviewedMolecular Biology