Molecular BiologyNucleic Acids ResearchPeer-reviewed
The interferon-stimulated gene product HERC5 inhibits human LINE-1 retrotransposition with an ISGylation-independent mechanism
Kei Nishimori, Ahmad Luqman-Fatah, Yuzo Watanabe…·Tomoichiro Miyoshi
This study identifies HERC5 as an ISGylation-independent inhibitor of L1 retrotransposition by reducing ORF1p levels and preventing L1 RNP assembly.
2 citations