Identification of mycobacterial efflux pump inhibiting compounds from Berberis holstii Engl. and determination of their mechanism of action
Ephantus G. Ndirangu, Caroline Maina, Edwin Kimathi Murungi, Margaret Mwihaki Ng’ang’a, Robi Chacha, Kehongo Nyanguru, Sospeter Ngoci Njeru, Nuhu T. Tukur, Gabriel T. Mashabela, Digby Francis Warner, Paul R. Race, Elizabeth Mumbi Kigondu
This study identifies compounds from Berberis holstii that inhibit Mycobacterium tuberculosis efflux pumps, showing synergistic effects with spectinomycin.
bioRxiv · Aug 15, 2025 · PreprintMicrobiology