Resolving human α versus β cell fate allocation for the generation of stem cell-derived islets
Melis Akgün Canan, Corinna Cozzitorto, Michael Sterr, Lama Saber, Eunike Sawitning Ayu Setyono, Alessandro Dema, Kei Kozawa, Xianming Wang, Juliane Merl‐Pham, Tobias Greisle, Ingo Burtscher, Heiko Lickert
The paper investigates human α and β cell fate allocation in stem cell-derived islets, revealing a distinct regulatory mechanism compared to mice and identifying pharmacological strategies to enhance cell fate commitment.
Nature Communications · Jul 9, 2026Peer-reviewedCell Biology