Juliane Merl‐Pham

MAFA drives pancreatic islet maturation through coordination of cell growth, metabolic maturation, and resilience to stress.

This study shows that MAFA promotes pancreatic islet maturation by enhancing cell growth, metabolic function, and stress resilience in stem cell-derived islets.

RTTN moonlights beyond the centrosome to control ribosome biogenesis and tRNA modification in human brain organoids

This study identifies RTTN's role in ribosome biogenesis and tRNA modification in human brain organoids, showing mutations disrupt translation and cause cortical malformations.

Concomitant post-translational repression of Arabidopsis PIP1 aquaporins upon the loss of major PIP2 isoforms

The paper shows that loss of major PIP2 isoforms in Arabidopsis leads to post-translational repression of PIP1 aquaporins, linking the two subfamilies functionally.

Resolving human α versus β cell fate allocation for the generation of stem cell-derived islets

The paper investigates human α and β cell fate allocation in stem cell-derived islets, revealing a distinct regulatory mechanism compared to mice and identifying pharmacological strategies to enhance cell fate commitment.

miR-940 suppresses ferroptosis by controlling expression of key regulatory genes

This study identifies miR-940 as a negative regulator of ferroptosis, showing it suppresses cell death by modulating key genes and GPX4 levels in cancer cells.

Hmgb2 improves astrocyte to neuron conversion by increasing the chromatin accessibility of genes associated with neuronal maturation in a proneuronal factor-dependent manner

The paper shows that Hmgb2 enhances astrocyte-to-neuron conversion by regulating chromatin accessibility of neuronal maturation genes in response to growth factors.

GGA2-depletion in beta cells by Enteroviruses causes Golgi acidification, premature activation of cathepsins and alters the MHC class I immunopeptidome

This study shows that EVs deplete GGA2 in beta cells, causing Golgi acidification and altering the MHC class I immunopeptidome through premature cathepsin activation.

TGIF2 is a major regulator of neural stem cell fate and neurogenic priming

The paper identifies TGIF2 as a key regulator of neural stem cell fate and neurogenic priming through transcriptomic and chromatin analysis in mouse brain development.

Depletion of the RNA-binding protein PURA triggers changes in posttranscriptional gene regulation and loss of P-bodies

This study shows that PURA depletion affects posttranscriptional regulation and P-body formation, linking PURA Syndrome to neurodevelopmental disorders.

Collagen VI regulates motor circuit plasticity and motor performance by cannabinoid modulation

This study identifies a synaptic mechanism linking collagen VI to motor control through cannabinoid receptor interaction and shows that CB1R agonists can improve motor performance in a dystonia mouse model.

Epiblast morphogenesis is controlled by selective mRNA decay triggered by LIN28A relocation

The paper identifies LIN28A as a key factor in mRNA decay during epiblast morphogenesis, linking cell identity changes to embryonic growth through nucleo-cytoplasmic translocation.