Maternal DNMT3A-dependent de novo methylation of the zygotic paternal genome inhibits gene expression in the early embryo
Julien Richard Albert, Wan Kin Au Yeung, Keisuke Toriyama, Hisato Kobayashi, Ryutaro Hirasawa, Julie Brind’Amour, Aaron Bogutz, Hiroyuki Sasaki, Matthew C. Lorincz
The paper shows maternal DNMT3A promotes de novo methylation on the paternal genome in early embryos, which suppresses gene expression.
Nature Communications · Oct 27, 2020Peer-reviewedDevelopmental Biology