Aaron Bogutz

The elongation of Mest transcript into MestXL sustains, but does not initiate, the maternal allele bias of its convergent gene Copg2 during neurogenesis

The paper investigates the regulation of maternal allele bias in Copg2 during neurogenesis, showing it involves a two-step mechanism beyond MestXL-mediated interference.

Dual profiling of DNA modifications with enhancer features during the exit of naive pluripotency

The paper uses Methyl-ATAC and Methyl-CUT&Tag to study 5mC and 5hmC dynamics during mESC differentiation, revealing their role in enhancer regulation.

Genomic imprinting of the metabolic regulator gene Klf14 is regulated by a paternal sub-TAD anchored at Mest and a shared enhancer in mice.

This paper identifies a paternal sub-TAD and shared enhancer that regulate Klf14 genomic imprinting in mice, revealing a mechanism involving Mest and allele-specific CTCF binding.

Maternal DNMT3A-dependent de novo methylation of the zygotic paternal genome inhibits gene expression in the early embryo

The paper shows maternal DNMT3A promotes de novo methylation on the paternal genome in early embryos, which suppresses gene expression.

Evolution of imprinting via lineage-specific insertion of retroviral promoters

The paper shows that lineage-specific retroviral promoters drive the evolution of maternal imprinting by establishing DNA methylation at imprinted genes in mice and humans.