Matthew C. Lorincz

This study investigates DNA methylation changes in SetDB1-deficient mouse ESCs, revealing its role in silencing retrotransposons and imprinted regions through coordination with H3K9me3.

The paper shows that an ancestral LTR retrotransposon insertion in the common ancestor of Euarchontoglires drives lineage-specific genomic imprinting of ZDBF2 through post-fertilization transcription initiation.

The paper identifies imprinted genes in rat tissues, finds conservation of canonical imprints in embryos but divergence in extra-embryonic tissues, and discovers novel non-canonical imprints.

This study shows that most histone acetylation depends on transcription, as inhibition of transcription reduces histone acetylation and affects HAT recruitment and activity.

The paper shows maternal DNMT3A promotes de novo methylation on the paternal genome in early embryos, which suppresses gene expression.

The paper shows that lineage-specific retroviral promoters drive the evolution of maternal imprinting by establishing DNA methylation at imprinted genes in mice and humans.

The paper investigates ZFP57's role in epigenetic regulation, showing it maintains DNA methylation and repressive marks at imprinted regions but is not essential for silencing transposable elements.