Hisato Kobayashi

PANDA analyzes targeted bisulfite amplicon sequencing data to assess methylation patterns and heterogeneity at the read level.

The paper identifies maternal transcripts linked to zygote developmental potential and demonstrates their use in predicting blastocyst formation with high specificity.

This study shows that loss of DDM1 reduces biomass heterosis in Arabidopsis hybrids by disrupting DNA methylation and transcriptome stability, revealing a salicylic acid-independent epigenetic mechanism.

The paper shows that an ancestral LTR retrotransposon insertion in the common ancestor of Euarchontoglires drives lineage-specific genomic imprinting of ZDBF2 through post-fertilization transcription initiation.

The paper identifies imprinted genes in rat tissues, finds conservation of canonical imprints in embryos but divergence in extra-embryonic tissues, and discovers novel non-canonical imprints.

The paper identifies a shared supergene involved in sex chromosome turnover across three Takifugu species, showing repeated translocations of this supergene as the mechanism for sex determination locus changes.

The paper shows maternal DNMT3A promotes de novo methylation on the paternal genome in early embryos, which suppresses gene expression.

The paper shows that lineage-specific retroviral promoters drive the evolution of maternal imprinting by establishing DNA methylation at imprinted genes in mice and humans.

The paper shows that paternal age affects offspring behavior through epigenetic changes in sperm DNA methylation, leading to altered gene expression and neuronal abnormalities.