William Farnaby

The paper develops a NanoBRET assay to quantify intracellular GlyT1 target engagement in living cells, distinguishing intracellular from extracellular ligands and resolving structure-activity relationships.

The paper identifies a new mechanism of kinase inhibition through electrophilic modifications, revealing aspartate conjugation of ULK1 by a chloroacetamide warhead.

This study shows that frustration in the SMARCA2-VHL protein-protein interface correlates with PROTAC cooperativity, offering a framework for structure-based PROTAC design.

This study shows that the natural half-life of a target protein significantly affects degradation by degrader agents and highlights confounding factors in screening for protein degraders.