Author

Philipp S. Schmalhorst

Boehringer Ingelheim (Austria)ORCID 0000-0002-5795-0133Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Alessio CiulliiD· 1 shared Andreas BergneriD· 1 shared Christiane C. KofinkiD· 1 shared Emelyne DiersiD· 1 shared Gerd BaderiD· 1 shared Harald WeinstabliD· 1 shared Keith Le· 1 shared Kyra Sankar· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiophysics

Alessio CiulliORCID

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1 paper

Recent·Most cited

Frustration in the Protein-Protein interface Plays a Central Role in the Cooperativity of PROTAC Ternary Complexes

Ning Ma, S. Bhattacharya, Sanychen Muk, Zuzana Jandová, Philipp S. Schmalhorst, Soumadwip Ghosh, Keith Le, Emelyne Diers, Nicole B. Trainor, William Farnaby, Michael J. Roy, Christiane C. Kofink, Peter Greb, Harald Weinstabl, Alessio Ciulli, , Nagarajan Vaidehi

This study shows that frustration in the SMARCA2-VHL protein-protein interface correlates with PROTAC cooperativity, offering a framework for structure-based PROTAC design.

Nature Communications · Sep 29, 2025Peer-reviewedBiophysics