Pro-resolving lipid mediators within brain esterified lipid pools are reduced in female rats chronically exposed to traffic-related air pollution or genetically susceptible to Alzheimer's Disease phenotype
Qing Xiang Shen, Nuanyi Liang, Kelley T. Patten, Yurika Otoki, Anthony E. Valenzuela, Christopher Wallis, Keith J. Bein, Anthony S. Wexler, Pamela J. Lein, Ameer Y. Taha
This study finds that female rats with Alzheimer's Disease risk genes or exposed to traffic-related air pollution show reduced brain esterified pro-resolving lipid mediators, suggesting sex-specific impacts on inflammation resolution.
bioRxiv · Feb 16, 2022 · PreprintNeuroscience