Pamela J. Lein

This study shows that transferring PCB-exposed gut microbiota to offspring reproduces neurobehavioral deficits and induces sex-biased molecular changes in the brain.

This study shows chronic NLRP3 inflammasome activation leads to neutrophil entry into the brain and interactions with microglia, contributing to CNS pathology.

The paper investigates how PCB exposure interacts with MeCP2 mutations in female mice, identifying shared gene pathways and transcriptional impacts in the cortex.

This study maps TRAP-derived nanoparticles in an Alzheimer model, finding sex- and region-specific effects on neuroinflammation and plaque interactions.

This study uses single-cell RNA sequencing to show that maternal PCB exposure alters cell type-specific gene expression and pathways in the liver of female offspring, affecting metabolic and immune functions.

The paper investigates sex-specific transcriptional responses to prenatal PCB exposure in mouse brain and placenta, finding female protective effects mediated by metabolic gene networks.

This study shows that alpha4 nicotinic acetylcholine receptors are required for organophosphate-induced neuronal hyperexcitability in vitro and in vivo.

This study uses a rat primary cortical tri-culture model to show that microglia in co-culture with neurons and astrocytes more effectively clear amyloid-beta and exhibit altered motility compared to co-culture or mono-culture.

The paper identifies placental DNA methylation modules associated with maternal PCB levels and child neurodevelopmental outcomes in the MARBLES cohort.

This study examines DNA methylation changes in mouse placenta and fetal brain after prenatal PCB exposure, finding shared differentially methylated regions linked to neurodevelopmental disorders.

This study finds that female rats with Alzheimer's Disease risk genes or exposed to traffic-related air pollution show reduced brain esterified pro-resolving lipid mediators, suggesting sex-specific impacts on inflammation resolution.

The paper develops a high-throughput phenotyping protocol for zebrafish larvae to assess autism-related mutant models, identifying morphological and behavioral defects in syngap1b and slc7a5 mutants.

This paper introduces a tri-culture model of neurons, astrocytes, and microglia that mimics in vivo neuroinflammatory responses to various insults.