Anthony E. Valenzuela

Female cortical cellular mosaicism underlies shared MeCP2 and PCB impacted gene pathways

The paper investigates how PCB exposure interacts with MeCP2 mutations in female mice, identifying shared gene pathways and transcriptional impacts in the cortex.

Spatial and spectral mapping of traffic-related air pollution (TRAP) nanoparticles in relation to plaques and inflammatory markers in an Alzheimer disease model

This study maps TRAP-derived nanoparticles in an Alzheimer model, finding sex- and region-specific effects on neuroinflammation and plaque interactions.

Placental-brain axis in females detected within broadly impacted metabolic gene networks protects against prenatal PCB exposure

The paper investigates sex-specific transcriptional responses to prenatal PCB exposure in mouse brain and placenta, finding female protective effects mediated by metabolic gene networks.

Genome-Wide DNA Methylation Profiles of Neurodevelopmental Disorder Genes in Mouse Placenta and Fetal Brain Following Prenatal Exposure to Polychlorinated Biphenyls

This study examines DNA methylation changes in mouse placenta and fetal brain after prenatal PCB exposure, finding shared differentially methylated regions linked to neurodevelopmental disorders.

Pro-resolving lipid mediators within brain esterified lipid pools are reduced in female rats chronically exposed to traffic-related air pollution or genetically susceptible to Alzheimer's Disease phenotype

This study finds that female rats with Alzheimer's Disease risk genes or exposed to traffic-related air pollution show reduced brain esterified pro-resolving lipid mediators, suggesting sex-specific impacts on inflammation resolution.