Nuanyi Liang

Metabolic Alteration in Oxylipins and Endocannabinoids Point to an Important Role for Soluble Epoxide Hydrolase and Inflammation in Alzheimer's Disease - Finding from Alzheimer's Disease Neuroimaging Initiative.

The paper analyzes metabolites in AD patients to show inflammation and sEH dysregulation, with sex and disease stage differences, and identifies markers of disease progression and cognitive resilience.

APOE Genotype Influences on The Brain Metabolome of Aging Mice - Role for Mitochondrial Energetics in Mechanisms of Resilience in APOE2 Genotype.

This study examines how APOE genotypes affect brain metabolome changes with aging in mice, finding that APOE2 genotype is associated with better mitochondrial function and BCAA utilization.

Whey Protein Phospholipid Concentrate Supplementation Prevents High-Fat Diet Induced Cognitive Impairment in Wistar Rats by Promoting Brain Neuronal Connectivity and Sphingolipid Clearance

WPPC supplementation prevents high-fat diet-induced cognitive impairment in rats by improving neuronal connectivity and reducing sphingolipid levels in the hippocampus.

Pro-resolving lipid mediators within brain esterified lipid pools are reduced in female rats chronically exposed to traffic-related air pollution or genetically susceptible to Alzheimer's Disease phenotype

This study finds that female rats with Alzheimer's Disease risk genes or exposed to traffic-related air pollution show reduced brain esterified pro-resolving lipid mediators, suggesting sex-specific impacts on inflammation resolution.