Commissureless acts as a substrate adapter in a conserved Nedd4 E3 ubiquitin ligase pathway to promote axon growth across the midline
Kelly G. Sullivan, Greg J. Bashaw
This study identifies Commissureless as a substrate adapter for the Nedd4 E3 ubiquitin ligase, promoting axon growth across the midline by facilitating Robo1 ubiquitination and degradation.
eLife · May 23, 2025Peer-reviewedNeuroscience