Epigenetic Control of TERRA by FTSJ3 is Critical for Telomerase-Driven Cancers
Jared D. W. Price, Frederick S. Vizeacoumar, Omar Abuhussein, Vincent Maranda, Yue Zhang, Hironori Adachi, Liliia Kyrylenko, Aline Rangel Pozzo, He Dong, Li Hui Gong, Prachi Walke, Ashtalakshmi Ganapathysamy, Connor Denomy, Tanya Freywald, Renuka Dahiya, , Franco J. Vizeacoumar
The paper identifies FTSJ3 as a critical vulnerability in hTERT-overexpressing cancers by showing its role in TERRA methylation and telomeric heterochromatin stability.
bioRxiv · Jan 26, 2025 · PreprintCancer Biology