Genetic ancestry shapes context-dependent immune regulation across Indigenous South American populations
Cecily Choy, Lucas Vicuña, Maria Patino, Daniel S. Araújo, Daisy Obispo, María L. Guevara, Susanne Fonseca, Débora Scariot, Cherly Araujo, João Ricardo Guerreiro, Óscar Acosta, Camille Johnson, Kevin Meier, Anne Dumaine, Kelly Williams, , Luis Bruno Barreiro
The paper generates a single-cell transcriptional atlas of Indigenous South American populations and shows genetic ancestry influences immune gene expression, particularly after stimulation.
medRxiv · Oct 21, 2026 · PreprintGenetic & Genomic Medicine