Brian S. Roberts

The paper identifies hsa-miR-206 as a sensitive and specific plasma biomarker for ALS using small-RNA sequencing and machine learning, validated by ddPCR in an independent cohort.

DegCre associates differential gene expression with regulatory regions using probabilistic correlation analysis across perturbation data.

The paper identifies cis-regulatory elements (cCREs) controlling MAPT expression and links genetic variation in these elements to Alzheimer's disease risk.

The paper shows that MPRA data exhibit strand asymmetry favoring naturally transcribed strands, suggesting biological functions driving this effect across gene bodies and Alu elements.

The paper analyzes miRNA expression dynamics across mouse embryonic development, identifying tissue-specific clusters and their regulatory roles.

The paper introduces MAD-DASH, a CRISPR/Cas9-based method to remove adapter dimers and highly expressed smRNAs from small RNA sequencing libraries, improving quantification of low-abundance species.

aRNApipe is a modular RNA-seq processing pipeline designed for HPC environments, offering efficient workflow management and customizable analysis modules.