Sara J. Cooper

This study identifies HDAC1's role in promoting multidrug resistance in pancreatic cancer through chromatin remodeling and develops a prognostic gene signature.

The paper analyzes genomic data from early-onset and atypical dementia patients to show that both rare and common genetic variations contribute to dementia risk.

The paper identifies cis-regulatory elements (cCREs) controlling MAPT expression and links genetic variation in these elements to Alzheimer's disease risk.

The paper uses CRISPR screens to identify co-repressor complexes as mediators of drug resistance in pancreatic cancer by regulating epithelial-to-mesenchymal transition.

The paper identifies and characterizes HOT loci with high DAP associations, finds driver motifs, and shows their regulatory importance through mutagenesis.

R2DGC aligns and identifies peaks in 2D gas chromatography-mass spectrometry data without thresholds, using R.

The paper presents a genome-wide interactome of DNA-associated proteins in human liver tissue, revealing binding patterns more consistent with liver biology than cell lines and highlighting non-coding variation impacts.

The paper compares transcriptomes and metabolomes of postmortem brain samples from schizophrenia, bipolar disorder, major depressive disorder, and controls to identify molecular differences and potential therapeutic targets.

aRNApipe is a modular RNA-seq processing pipeline designed for HPC environments, offering efficient workflow management and customizable analysis modules.