Dysregulated synaptic gene expression in oligodendrocytes of spinal and bulbar muscular atrophy
Madoka Iida, Kentaro Sahashi, Tomoki Hirunagi, Kenji Sakakibara, Kentaro Maeda, Yohei Iguchi, Jiayi Li, Yosuke Ogura, Masaki Iizuka, Tomohiro Akashi, Kunihiko Hinohara, Shouta Sugio, Hiroaki Wake, Masahiro Nakatochi, Masahisa Katsuno
This study identifies dysregulated synaptic gene expression in oligodendrocytes of SBMA mice, highlighting early cell-to-cell communication changes as a potential therapeutic target.
JCI Insight · Jun 22, 2025Peer-reviewedNeuroscience